Most instances of generalized vaccinia, particularly if the lesions are few, require no specific therapy. In some cases, with extensive lesions, or in recurrent disease, Vaccinia Immune Globulin (VIG) should be administered in an initial dose of 0.6 ml per kg body weight. Rarely is it necessary to administer more than one course with recurrent disease.
If an antibody (B-cell) deficient state or another immunologic abnormality is diagnosed, then both VIG therapy for the viral disease and appropriate therapy for the immunologic deficiency must be decided in consultation with an immunologist.
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