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In general, the rashes are benign, with the exception of the rarely encountered Stevens-Johnson Syndrome. The underlying mechanism is uncertain and may be either allergic or toxic or both.
There appears to be no predilection for these rashes, although some believe that allergic persons may be more likely to develop them. Immunologic data on affected vaccinees is lacking. Some investigators believe that a concurrent enterovirus infection causes the rash but data are insufficient to determine if this is a true association.
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