It is estimated that there are 27 million individuals in the United States in 2002 who have atopic dermatitis,
many of whom would be susceptible to eczema vaccinatum if vaccinated or in contact with a vaccinee.
Further, it appears that even healed skin is not normal and eczema vaccinatum has occurred in the skin of such
individuals at the sites of prior florid eczema.
Eczema
Vaccinatum (EV) Cases per 1,000,000 Primary Vaccinations(*)
|
|
Age (yrs)
|
1968 National
Survey(†)
|
1968 10-State
Survey(§)
|
| 1-4 |
11.7 |
47.3 |
| 5-19 |
6.3 |
34.9 |
| >20 |
24.0 |
30.3 |
| Totals >1 yr |
10.6 |
41.5 |
* |
Numbers rounded to the nearest
tenth, total number of vaccinations estimated in both studies.
Observations missing age were distributed according to the existing
age distribution for EV. |
| † |
Case sources include: American
Red Cross Vaccinia Immune Globulin (VIG) distribution system,
Red Cross VIG consultants, State and Territorial Epidemiologists,
Burroughs-Wellcome Thiosemicarbazone distribution list, smallpox
vaccine manufacturers complication reporting files, state reports
to the Encephalitis Surveillance Unit of the National Communicable
Disease Center (NCDC), and specimen submissions for vaccinia
testing to the Viral Exanthems Unit of NCDC. |
| § |
Case sources include: Physician
reporting via survey in 10 states with active case information
follow-up and chart review for post-vaccinial encephalitis and
vaccinia necrosum reports. |
|
