Smallpox: Diagnosis/Evaluation
Information for the public can be found on the Smallpox Disease page.
On this page:
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Highlights
- Risk Evaluation Algorithm: Evaluate a Rash Illness Suspicious for Smallpox
- Acute, Generalized Vesicular or Pustular Rash Illness Testing Protocol in the United States
- Smallpox Response Plan & Guidelines
Diagnosis Tools
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Risk Evaluation Algorithm: Evaluate a Rash Illness Suspicious for Smallpox
Use this online form to instantly evaluate a rash illness suspicious for smallpox
May 21, 2004
(last reviewed Feb 21, 2006) -
Poster: Evaluating Patients for Smallpox
Evaluation protocol, risk evaluation, chickenpox-smallpox comparison, common conditions comparison...
Jun 28, 2004
(last reviewed Feb 21, 2006) -
Worksheet: Evaluating Patients for Smallpox
(182 KB/4 pages)
Standard worksheet for evaluating patients for smallpox. Use this investigation form for collecting information on cases of acute, generalized vesicular or pustular rash illness & to classify risk of smallpox using CDC criteria outlined in the poster ("Evaluating Patients for Smallpox").
Mar 4, 2002
(last reviewed Feb 21, 2006) -
Smallpox
Case Definitions
Includes clinical case definition, lab criteria for confirmation, case classification, clinical types of variola major
Dec 31, 2003
(last reviewed Feb 21, 2006) -
Laboratory Testing
- Acute, Generalized Vesicular or Pustular Rash Illness Testing Protocol in the US (569 KB/5 pages)
Protocol developed to illustrate types of lab testing for patients with acute, generalized vesicular or pustular rash illness
November 14, 2007 -
Negative Staining Electron Microscopic Protocol for Rash Illness (458 KB/8 pages)
Instructions for laboratorians
April 8, 2005
(last reviewed Feb 21, 2006) -
Images
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Smallpox: Images
Images of smallpox disease and vaccination reaction -
Training
- Course: Smallpox: Disease, Prevention, & Intervention
Developed by CDC & WHO for training smallpox response teams
Dec 22, 2003
(last reviewed Feb 21, 2006) - Online Training: Smallpox: What Every Clinician Should Know (interactive version)
Provides information for clinicians on clinical features, diagnosis, & treatment of smallpox & the characteristics & use of smallpox vaccine. -
Video: Smallpox: What Every Clinician Should Know (video version)
May 8, 2003
(last reviewed Feb 21, 2006) -
Rash Illness Evaluation
From the webcast "CDC Bioterrorism Update: Smallpox Preparedness"
Feb 21, 2003
(last reviewed Feb 21, 2006) -
References
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Consensus Statement: Smallpox as a Biological Weapon: Medical & Public Health Management
JAMA 1999 Jun 9;281(22):2127-2137.
PDF (361 KB/11 pages)
Abstract
Concise, bulleted summary of the full article
PDF (165 KB/6 pages)Jun 9, 1999 -
Smallpox Response Plan & Guidelines
Provides direction to state & local health officials for responding to a smallpox emergency.
Jun 23, 2004
(last reviewed Feb 21, 2006) - Isolation & Quarantine Guidelines (Guide C)
From the Smallpox Response Plan and Guidelines (Version 3.0)
(22 pages total, broken into 2 sections)
PDF (236 KB/14 pages)
PDF (174 KB/8 pages) -
Specimen Collection Guidelines (Guide D)
From the Smallpox Response Plan and Guidelines (Version 3.0)
PDF (239 KB/12 pages) -
Epidemiology and Prevention
of Vaccine-Preventable Diseases: Smallpox Chapter (963 KB/24 pages)
The Pink Book
January 2005 -
Recognition of Illness Associated with the Intentional Release of a Biologic Agent
MMWR 2001 Oct 19;50(41):893-897.
PDF (168 KB/20 pages) -
Historical Archives
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Video: Virology & Diagnosis of Smallpox
Archived video webcast from the International Conference on Emerging Infectious Diseases (ICEID)
Russell Regnery, CDC, Atlanta, GA
March 25, 2002 -
Video: Clinical & Epidemiologic Features of Smallpox
Archived video webcast from the International Conference on Emerging Infectious Diseases (ICEID)
Stanley Foster, Rollins School of Public Health, Emory University, Atlanta, GA
March 25, 2002