Immunohistochemical staining of the organism can be considered
confirmatory when isolation or serological confirmation is not
Laboratory confirmation is especially important for the first
cases in a geographic area, as they will lead to treatment and
isolation of additional suspected cases, post or preexposure
prophylaxis of those exposed, and other control measures.
Contact your public health department immediately if you suspect
plague so that the proper measures can be taken as early as
possible. It is required by law to report any suspect plague
cases to CDC within 24 hours of the initial examination.