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Plague  Lesson 4
 Laboratory Issues - Clinicians

Laboratory Results for Case Classification - Probable

  • Definition
    • Clinical symptoms or exposure compatible with plague.
    • The specimen or recovered isolate is positive by any one of the following tests:
      • Direct fluorescent antibody (DFA) staining.
      • DNA detection by PCR or plasmids.
      • Immunohistochemical staining (IHC).


    • Single serum specimen that has a minimum passive hemagglutination/inhibition (PHA/HI) titer of greater than or equal to 1:10 or a positive enzyme-linked immunoassay (ELISA) titer. Known negative and positive serum samples must be run together with test samples on each test.
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Page last reviewed February 12, 2007
Page last modified September 7, 2004

  • Content source: CDC Emergency Risk Communication Branch (ERCB), Division of Emergency Operations (DEO), National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
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