Diseases to Consider - Acute lymphadenitis
associated with bubonic plague must be differentiated from other
causes. You should note that the bubo is exquisitely tender,
whereas that is not generally the case with these other diseases.
Also, with plague, a rapid onset of fever accompanies the lymph
node swelling. Other causes can be:
Appendicitis - abdominal mesenteric nodes become painful
from infective flea bites to the trunk.
Capnocytophaga canimorsus - from animal bites or scratches.
Cellulitis - They produce localizing lymphadenopathy.
Non-specific Infections - May produce localized, unilateral